Regulation of early adenovirus gene expression.

INTRODUCTION ........................................ 419 GENE ORGANIZATION ........................................ 419 TEMPORAL EXPRESSION OF EARLY GENES ........................................ 420 TRANSCRIPTION CONTROL........................................ 421 ACTIVATION OF TRANSCRIPTION BY ElA 421 Mechanism for E1A Action ........................................ 423 E2F Factor ........................................ 423 Basis for Control of E2F by ElA ........................................ 424 Coordinate Control of Transcription ........................................ 424 REPRESSION OF TRANSCRIPTION BY ElA ........................................ 425 TRANSCRIPTION CONTROL AND ONCOGENESIS ........................................ 426 SUMMARY AND PERSPECTIVES........................................426 LITERATURE CITED........................................ 427